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DeCS
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Descriptor English:
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RNA, Small Interfering
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Descriptor Spanish:
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ARN Interferente Pequeño
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Descriptor Portuguese:
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RNA Interferente Pequeno
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Synonyms English:
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Piwi-Interacting RNA
Repeat-Associated siRNA
RNA, Piwi-Interacting
RNA, Scan
Scan RNA
siRNA
siRNA, Repeat-Associated
siRNA, Trans-Acting
Small Scan RNA
Trans-Acting siRNA
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Tree Number:
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D13.150.650.700
D13.444.735.150.700
D13.444.735.790.552.875
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Definition English:
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Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions. |
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Indexing Annotation English:
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Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
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See Related English:
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MicroRNAs
RNA Interference
RNA-Induced Silencing Complex
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History Note English:
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2003; use RNA, SMALL INTERFERING (NM) 2001-2002
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Allowable Qualifiers English:
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Record Number:
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37536
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Unique Identifier:
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D034741
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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